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laeverin; CHL2 antigen (LVRN, AQPEP)
Function:
1) probable metalloprotease
2) role in extravillous trophoblasts function
3) binds 1 Zn+2 per subunit
Structure: belongs to the peptidase M1 family
Compartment:
- membrane
Alternative splicing: named isoforms=4
Expression:
- specifically expressed in placenta & NOT in other tissues
- found at the cell surface region of extravillous trophoblasts
- detected on extravillous trophoblasts in the outer layer of chorion laeve in the fetal membrane
- not detected on either fetal amniotic epithelial cells or maternal decidual cells
- also detected in the migrating extravillous trophoblasts in the maternal decidual tissues
General
glycoprotein
membrane protein
metalloprotease
Properties
SIZE: MW = 113 kD
entity length = 990 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {14-34}
N-glycosylation site {N132}
N-glycosylation site {N168}
N-glycosylation site {N261}
N-glycosylation site {N288}
N-glycosylation site {N319}
N-glycosylation site {N346}
Zn+2-binding site
SITE: 415-415
glutamate residue {E416}
Zn+2-binding site
SITE: 419-419
Zn+2-binding site
SITE: 438-438
tyrosine residue {Y503}
N-glycosylation site {N607}
N-glycosylation site {N653}
Database Correlations
UniProt Q6Q4G3
Pfam PF01433
References
UniProt :accession Q6Q4G3