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ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; functional smad-suppressing element on chromosome 18; fussel-18 (CORL2, FUSSEL18, SKOR2)
Function:
- acts as a TGF-beta antagonist in the nervous system
- interacts with SMAD2 & SMAD3
Structure: belongs to the SKI family
Compartment: nucleus, cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in cerebellum, spinal cord & testis
- isoform 2 is present in cerebellum (at protein level)
General
nuclear protein
Properties
SIZE: entity length = 1001 aa
MW = 104 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: alanine-rich region {261-448}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 285-294
MOTIF: proline residue (SEVERAL)
glycine-rich region {343-616}
proline-rich region
SITE: 465-711
MOTIF: proline residue (SEVERAL)
histidine-rich region {603-668}
MOTIF: histidine residue (SEVERAL)
glutamate-rich region {729-774}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 834-840
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt Q2VWA4
PFAM correlations
References
UniProt :accession Q2VWA4