kynureninase; L-kynurenine hydrolase (KYNU)

Function: - catalyzes the cleavage of L-kynurenine & L-3-hydroxykynurenine into anthranilate & 3-hydroxyanthranilate, respectively - preference for the L-3-hydroxykynurenine - also has cysteine-conjugate-beta-lyase activity (putative) - inhibited by o-methoxybenzoylalanine - amino-acid degradation, L-kynurenine degradation - L-alanine & anthranilate from L-kynurenine: step 1/1 - cofactor biosynthesis; NAD⁺ biosynthesis - pyridine-2,3-dicarboxylate from L-kynurenine: step 2/3 L-kynurenine + H₂O anthranilate + L-alanine L-3-hydroxykynurenine + H₂O 3-hydroxyanthranilate + L-alanine Cofactor: pyridoxal phosphate Structure: - homodimer (putative) - belongs to the kynureninase family Compartment: cytoplasm Expression: - expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney & pancreas) - highest levels found in placenta, liver & lung - expressed in all brain regions - increased levels in several cerebral & systemic inflammatory conditions

Properties

SIZE: entity length = 465 aa MW = 52 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl cofactor-binding site [276-276] FOR-BINDING-OF: pyridoxal phosphate

Database Correlations

OMIM 605197 UniProt Q16719 Pfam PF00266 Kegg hsa/hsa00380 ENZYME 3.7.1.3

References

UniProt :accession Q16719