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Kv4.2/KCNIP2 channel complex
Structure:
- octamer consisting of Kv4.2 (4), KCNIP2 (4)
General
membrane protein
molecular complex
Properties
COMPARTMENT: cell nucleus
MOTIF: membrane region
SUBUNITS: K+ voltage-gated channel subfamily D member 2 (4)
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-183}
MOTIF: KCNIP2 interaction {2-20}
KCNIP1 interaction {7-11}
Thr phosphorylation site {T38}
KCNIP1 interaction {71-90}
Zn+2-binding site
SITE: 105-105
Zn+2-binding site
SITE: 132-132
Zn+2-binding site
SITE: 133-133
transmembrane domain {184-204}
exoplasmic loop {205-224}
transmembrane domain {225-245}
cytoplasmic loop {246-259}
transmembrane domain {260-280}
exoplasmic loop {281-289}
transmembrane domain {290-310}
cytoplasmic loop {311-323}
transmembrane domain {324-344}
exoplasmic loop {345-384}
MOTIF: peptide motif {370-375}
transmembrane domain {385-405}
cytoplasmic domain {406-630}
MOTIF: Ser phosphorylation site {S548}
Ser phosphorylation site {S552}
Thr phosphorylation site {T602}
Thr phosphorylation site {T607}
Ser phosphorylation site {S616}
ION-PERMEABILITY: K+
Kv channel-interacting protein 2 (4)
COMPARTMENT: cellular membrane
MOTIF: cysteine residue {C45}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C46}
MODIFICATION: palmitate
COMPARTMENT: membrane
EF hand
SITE: 81-137
EF hand
SITE: 140-175
EF hand
SITE: 176-211
EF hand
SITE: 224-259
MOTIF: Ca+2-binding site
SITE: 237-248
binding site
SITE: 257-270
FOR-BINDING-OF: K+ voltage-gated channel subfamily D member 2
References
UniProt :accession Q9NS61
Components
K+ voltage-gated channel subfamily D member 2; voltage-gated K+ channel subunit Kv4.2 (KCND2, KIAA1044)
Kv channel-interacting protein 2; KChIP2; A-type K+ channel modulatory protein 2; K+ channel-interacting protein 2; cardiac voltage gated K+ channel modulatory subunit (KCNIP2, KCHIP2)