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Kunitz-type protease inhibitor 2; hepatocyte growth factor activator inhibitor type 2; HAI-2; placental bikunin (SPINT2, HAI2, KOP)
Function:
- inhibitor of HGF activator
- also inhibits plasmin, plasma kallikrein & tissue kallikrein, & factor XIa
Structure:
- contains 2 BPTI/Kunitz inhibitor domains
Compartment:
- membrane
- single-pass type 1 membrane protein (putative)
Expression:
- expressed in placenta, kidney, pancreas, prostate, testis, thymus, & trachea
Pathology:
- defects in SPINT2 are the cause of hereditary diarrhea type 3
General
glycoprotein
Kunitz type serine protease inhibitor
membrane protein
Properties
SIZE: entity length = 252 aa
MW = 28 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-27}
BPTI/Kunitz inhibitor 1 {38-88}
MOTIF: cysteine residue {C38}
MODIFICATION: cysteine residue {C88}
cysteine residue {C47}
MODIFICATION: cysteine residue {C71}
peptide motif {48-49}
N-glycosylation site {N57}
cysteine residue {C63}
MODIFICATION: cysteine residue {C84}
cysteine residue {C71}
MODIFICATION: cysteine residue {C47}
cysteine residue {C84}
MODIFICATION: cysteine residue {C63}
cysteine residue {C88}
MODIFICATION: cysteine residue {C38}
N-glycosylation site {N94}
BPTI/Kunitz inhibitor 2 {133-183}
MOTIF: cysteine residue {C133}
MODIFICATION: cysteine residue {C183}
cysteine residue {C142}
MODIFICATION: cysteine residue {C166}
peptide motif {143-144}
cysteine residue {C158}
MODIFICATION: cysteine residue {C179}
cysteine residue {C166}
MODIFICATION: cysteine residue {C142}
cysteine residue {C179}
MODIFICATION: cysteine residue {C158}
cysteine residue {C183}
MODIFICATION: cysteine residue {C133}
transmembrane domain {198-218}
INHIBITS: serine protease
Database Correlations
OMIM correlations
MORBIDMAP 605124
UniProt O43291
Pfam PF00014
Entrez Gene 10653
Kegg hsa:10653
References
UniProt :accession O43291