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Kunitz-type protease inhibitor 1; hepatocyte growth factor activator inhibitor type 1; HAI-1 (SPINT1 HAI1 UNQ223/PRO256)
Function:
- inhibitor of HGF activator
- also acts as an inhibitor of matriptase (ST14)
- interacts with HGFAC
Structure:
- contains 2 BPTI/Kunitz inhibitor domains
- contains 1 LDL-receptor class A domain
- contains 1 MANSC domain
Compartment: secreted
Alternative splicing: named isoforms=2
General
glycoprotein
Kunitz type serine protease inhibitor
secreted protein
Properties
SIZE: entity length = 529 aa
MW = 58 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-35}
MANSC {57-140}
MOTIF: N-glycosylation site {N66}
N-glycosylation site {N235}
BPTI/Kunitz inhibitor 1 {250-300}
MOTIF: cysteine residue {C250}
MODIFICATION: cysteine residue {C300}
cysteine residue {C259}
MODIFICATION: cysteine residue {C283}
peptide motif {260-261}
cysteine residue {C275}
MODIFICATION: cysteine residue {C296}
cysteine residue {C283}
MODIFICATION: cysteine residue {C259}
cysteine residue {C296}
MODIFICATION: cysteine residue {C275}
cysteine residue {C300}
MODIFICATION: cysteine residue {C250}
LDL-receptor class A {334-370}
MOTIF: cysteine residue {C335}
MODIFICATION: cysteine residue {C347}
cysteine residue {C342}
MODIFICATION: cysteine residue {C360}
cysteine residue {C347}
MODIFICATION: cysteine residue {C335}
cysteine residue {C354}
MODIFICATION: cysteine residue {C369}
cysteine residue {C360}
MODIFICATION: cysteine residue {C342}
cysteine residue {C369}
MODIFICATION: cysteine residue {C354}
BPTI/Kunitz inhibitor 2 {391-441}
MOTIF: cysteine residue {C391}
MODIFICATION: cysteine residue {C441}
cysteine residue {C400}
MODIFICATION: cysteine residue {C424}
peptide motif {401-402}
cysteine residue {C416}
MODIFICATION: cysteine residue {C437}
cysteine residue {C424}
MODIFICATION: cysteine residue {C400}
cysteine residue {C437}
MODIFICATION: cysteine residue {C416}
cysteine residue {C441}
MODIFICATION: cysteine residue {C391}
N-glycosylation site {N523}
INHIBITS: serine protease
Database Correlations
OMIM 605123
UniProt O43278
PFAM correlations
Entrez Gene 6692
Kegg hsa:6692
References
UniProt :accession O43278