Krueppel-like factor 7; ubiquitous krueppel-like factor (KLF7, UKLF)

Function: - transcriptional activator - binds in vitro to the CACCC motif of the beta-globin promoter & to the SP1 recognition sequence Structure: - the acidic N-terminal part may favor interaction with the basic domain of transcription factors - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 3 C2H2-type Zn⁺² fingers Compartment: nucleus (probable) Expression: - ubiquitous - highly expressed in brain & spinal cord in adults highly expressed in kidney & brain in the embryo

Properties

SIZE: entity length = 302 aa MW = 33 kD COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {215-220} Zn finger C2H2-type SITE: 219-243 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 249-273 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 279-301 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 604865 UniProt O75840 Entrez Gene 8609 Kegg hsa:8609

References

UniProt :accession O75840