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Krueppel-like factor 5; basic transcription element-binding protein 2; BTE-binding protein 2; colon krueppel-like factor; GC-box-binding protein 2; intestinal-enriched krueppel-like factor; transcription factor BTEB2 (KLF5, BTEB2, CKLF, IKLF)
Function:
- transcription factor that binds to GC box promoter elements
- activates the transcription of these genes
- ubiquitinated
- polyubiquitination involves WWP1 & leads to proteasomal degradation
- interacts with WWP1
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: expressed only in testis & placenta
General
Krueppel-like factor
Properties
SIZE: entity length = 457 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: WWP1 interaction {324-328}
Zn finger C2H2-type
SITE: 373-397
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 403-427
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 433-455
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 602903
UniProt Q13887
Entrez Gene 688
Kegg hsa:688
References
- UniProt :accession Q13887
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/KLF5ID41074ch13q21.html