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Krueppel-like factor 3; basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2 (KLF3, BKLF)
Function:
- binds to the CACCC box of erythroid cell-expressed genes
- may play a role in hematopoiesis (putative)
- sumoylated by SUMO1
- sumoylation is enhanced by PIAS1, PIAS2alpha & PIAS2beta, & PIAS4, but not by Pc2
- enhances transcriptional repression, but has no effect on DNA binding
- sumoylation on Lys-198 is the major site (putative)
- monomer (putative)
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus (probable)
Alternative splicing:
- named isoforms=2
- at least one isoform may be due to intron retention
General
Krueppel-like factor
phosphoprotein
Properties
SIZE: entity length = 345 aa
MW = 39 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 1-251
MOTIF: proline residue (SEVERAL)
Repressor {1-74}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
CTBP-binding {61-65}
Ser phosphorylation site {S71}
Ser phosphorylation site {S92}
Ser phosphorylation site {S101}
Ser phosphorylation site {S250}
Zn finger C2H2-type
SITE: 260-284
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 290-314
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 320-342
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 609392
UniProt P57682
Entrez Gene 51274
Kegg hsa:51274
References
UniProt :accession P57682