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Krueppel-like factor 2; lung krueppel-like factor (KLF2, LKLF)
Function:
- binds to the CACCC box in the beta-globin gene promoter & activates transcription (putative)
- ubiquitinated
- polyubiquitination involves WWP1 & leads to proteasomal degradation
- interacts with WWP1
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus (putative)
General
Krueppel-like factor
Properties
SIZE: entity length = 355 aa
MW = 37 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 62-71
MOTIF: proline residue (SEVERAL)
WWP1 interaction {111-268}
MOTIF: glycine-rich region {130-135}
proline-rich region
SITE: 167-171
MOTIF: proline residue (SEVERAL)
alanine-rich region {225-231}
MOTIF: alanine residue (SEVERAL)
Zn finger C2H2-type
SITE: 272-296
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 302-326
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 332-354
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 602016
UniProt Q9Y5W3
Entrez Gene 10365
Kegg hsa:10365
References
- UniProt :accession Q9Y5W3
- SeattleSNPs
http://pga.gs.washington.edu/data/klf2/