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Krueppel-like factor 15; kidney-enriched krueppel-like factor (KLF15, KKLF)
Function:
- transcriptional activator
- binds to the GA element of the CLCNKA promoter
- KLF15 binds to the beta-adrenergic receptor ADRB1 & switches it off [2]
- KLF15 maintains white adipocytes selectively within white adipose tissue
- deletion of KLF15 is sufficient to induce beige adipocytes (brown fat) [2]
- direct regulation of ADRB1 is a molecular mechanism for this
Structure:
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression:
- expressed in liver > heart, skeletal muscle, kidney
- not expressed in bone marrow or lymphoid tissues
General
Krueppel-like factor
Properties
SIZE: entity length = 416 aa
MW = 44 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 321-345
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 351-375
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 381-403
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 606465
UniProt Q9UIH9
Entrez Gene 28999
Kegg hsa:28999
References
- UniProt :accession Q9UIH9
- Stewart J
Scientists May Finally Know How to Turn White Fat Into Brown.
Medscape. July 10, 2024
https://www.medscape.com/viewarticle/scientists-may-finally-know-how-turn-white-fat-brown-2024a1000co9
- Li L, Feldman BJ
White adipocytes in subcutaneous fat depots require KLF15 for maintenance
in preclinical models.
J Clin Invest. 2024 Jul 1;134(13):e172360
PMID: 38949025 PMCID: PMC11213504 Free PMC article.