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Krueppel-like factor 13; basic transcription element-binding protein 3; BTE-binding protein 3; Novel Sp1-like zinc finger transcription factor 1; RANTES factor of late activated T-lymphocytes 1; RFLAT-1; transcription factor BTEB3; transcription factor NSLP1 (KLF13, BTEB3, NSLP1)
Function:
- represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1
- also represses transcription by interacting with the corepressor sin3A & HDAC1
- activates RANTES expression in T-cells
- phosphorylated
Structure:
- the Ala/Pro-rich domain may contain discrete activation & repression subdomains & also can mediate protein-protein interactions
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: ubiquitous
General
Krueppel-like factor
Properties
SIZE: entity length = 288 aa
MW = 31 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 2-145
MOTIF: proline residue (SEVERAL)
alanine-rich region {2-5}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {113-116}
MOTIF: alanine residue (SEVERAL)
lysine-rich region {148-168}
MOTIF: lysine residue (SEVERAL)
Zn finger C2H2-type
SITE: 167-191
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 197-221
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 227-249
EFFECTOR-BOUND: Zn+2
serine-rich region {264-287}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 605328
UniProt Q9Y2Y9
Entrez Gene 51621
Kegg hsa:51621
References
UniProt :accession Q9Y2Y9