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Krueppel-like factor 12; transcriptional repressor AP-2rep (KLF12, AP2REP, HSPC122)
Function:
- confers strong transcriptional repression to the AP2-alpha gene
- binds to a regulatory element (A32) in the AP2-alpha gene promoter
Structure:
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
General
Krueppel-like factor
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 402 aa
MW = 44 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S202}
Zn finger C2H2-type
SITE: 317-341
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 347-371
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 377-399
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 607531
UniProt Q9Y4X4
Entrez Gene 11278
Kegg hsa:11278
References
UniProt :accession Q9Y4X4