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Kremen protein 2 (Kringle-containing protein marking the eye & the nose, Kringle domain-containing transmembrane protein 2, Dickkopf receptor 2, KREMEN2, KRM2)
Function:
- receptor for Dickkopf protein
- cooperates with Dickkopf to block Wnt/beta-catenin signaling
- forms a ternary complex with Dkk1 & LRP6 & induces rapid endocytosis & removal of Wnt receptor LRP6 from the plasma membrane
Structure:
- contains 1 CUB domain
- contains 1 kringle domain
- contains 1 WSC domain
Compartment: membrane
Alternative splicing: named isoforms=4
General
cell surface receptor
glycoprotein
Properties
SIZE: MW = 49 kD
entity length = 462 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-25}
Kringle {35-119}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C119}
N-glycosylation site {N49}
cysteine residue {C60}
MODIFICATION: cysteine residue {C100}
cysteine residue {C89}
MODIFICATION: cysteine residue {C114}
cysteine residue {C100}
MODIFICATION: cysteine residue {C60}
cysteine residue {C114}
MODIFICATION: cysteine residue {C89}
cysteine residue {C119}
MODIFICATION: cysteine residue {C36}
WSC {121-215}
CUB domain {219-326}
MOTIF: cysteine residue {C219}
MODIFICATION: cysteine residue {C245}
N-glycosylation site {N222}
N-glycosylation site {N244}
cysteine residue {C245}
MODIFICATION: cysteine residue {C219}
N-glycosylation site {N351}
transmembrane domain {365-387}
Database Correlations
UniProt Q8NCW0
PFAM correlations
References
UniProt :accession Q8NCW0