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Kremen protein 1; Kringle-containing protein marking the eye & the nose; Kringle domain-containing transmembrane protein 1; Dickkopf receptor (KREMEN1, KREMEN, KRM1)
Function:
- receptor for Dickkopf protein
- cooperates with Dickkopf to block Wnt/beta-catenin signaling
Structure:
- contains 1 CUB domain
- contains 1 kringle domain
- contains 1 WSC domain
Compartment: membrane
Alternative splicing: named isoforms=3
General
glycoprotein
membrane protein
Properties
SIZE: MW = 52 kD
entity length = 475 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
Kringle {33-116}
MOTIF: cysteine residue {C34}
MODIFICATION: cysteine residue {C116}
N-glycosylation site {N47}
cysteine residue {C57}
MODIFICATION: cysteine residue {C97}
N-glycosylation site {N61}
cysteine residue {C86}
MODIFICATION: cysteine residue {C111}
cysteine residue {C97}
MODIFICATION: cysteine residue {C57}
cysteine residue {C111}
MODIFICATION: cysteine residue {C86}
cysteine residue {C116}
MODIFICATION: cysteine residue {C34}
WSC {118-212}
CUB domain {216-323}
MOTIF: cysteine residue {C216}
MODIFICATION: cysteine residue {C242}
N-glycosylation site {N219}
cysteine residue {C242}
MODIFICATION: cysteine residue {C216}
N-glycosylation site {N295}
N-glycosylation site {N335}
N-glycosylation site {N347}
transmembrane domain {395-415}
Database Correlations
UniProt Q96MU8
PFAM correlations
References
UniProt :accession Q96MU8