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Kunitz-type serine protease inhibitor [KPI] domain
Kunitz-type serine protease inhibitor domain. Occurs in 751 & 771 amino-acid isoforms of the amyloid precursor protein (APP). In human platelets, this domain serves as an inhibitor of coagulation factor XIa.
Related
serine protease
General
serpin motif
cysteine-rich region
Properties
NAME: Kunitz-type serine protease inhibitor [KPI] domain
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+0}
FOR-BINDING-OF: serine protease
References
- Selkoe DJ.
Alzheimer's disease: genes, proteins, and therapy.
Physiol Rev. 2001 Apr;81(2):741-66. Review.
PMID: 11274343