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KPC complex
Function:
1) E3 ubiquitin-protein ligase
2) poly-ubiquitination & proteasome-mediated degradation of CDKN1B during G1 phase of cell cycle
Structure:
- subunits: RNF123/KPC1 & UBADC1/KPC2
General
molecular complex
Properties
SUBUNITS: E3 ubiquitin-protein ligase RNF123
COMPARTMENT: cytoplasm
MOTIF: B30.2/SPRY {74-254}
active site
alanine-rich region {1237-1244}
MOTIF: alanine residue (SEVERAL)
RING-finger {1254-1292}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
ubiquitin-associated domain-containing protein 1
COMPARTMENT: cytoplasm
MOTIF: UBIQUITIN-LIKE {14-98}
UBA 1 {187-231}
UBA 2 {288-328}
STI1 {353-392}
References
UniProt :accession Q5XPI4
Components
E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123 (RNF123, KPC1, FP1477)
ubiquitin-associated domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Kip1 ubiquitination-promoting complex protein 2; glioblastoma cell differentiation-related protein 1 (UBADC1, UBAC1, GBDR1, KPC2)