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Kluver-Bucy syndrome
1st described in 1975 in a patient with herpes encephalitis.
Etiology:
1) herpes encephalitis
2) Pick's disease
3) Alzheimer's disease
4) cerebral trauma
5) stroke
6) temporal lobe epilepsy
7) Huntington's chorea
8) hypoxia
9) hypoglycemia
10) subarachnoid hemorrhage
11) neuroleptics
12) heat stroke
Pathology:
- bilateral temporal lobe dysfunction
Clinical manifestations:
1) psychic blindness (monkeys)
2) hyper-reactivity to visual stimuli
3) visual agnosia
4) increased oral & sexual activity
5) depressed drive & emotional reactions
6) other manifestations that may occur
a) aphasia
b) amnesia
c) dementia
d) seizures
Management:
1) symptomatic & supportive
2) medroxyprogesterone [3]
3) androgen deprivation therapy [3]
4) SSRI may be helpful, but not 1st line [3]
5) prognosis
a) no cure, but not life-threatening
b) patient can be difficult to manage
c) symptoms may slowly decline with treatment
General
sign/symptom
References
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
- Lilly R et al, Neurology 33:1141, 1983
- Geriatric Review Syllabus, 7th edition
Parada JT et al (eds)
American Geriatrics Society, 2010
- NINDS Kluver-Bucy Syndrome Information Page
https://www.ninds.nih.gov/disorders/all-disorders/kl%C3%BCver-bucy-syndrome-information-page