KKXX/KXKXX ER retrieval signal

Some integral membrane proteins of the ER use a retrieval system to achieve ER localization. These proteins have type 1 topology with their C-terminus in the cytoplasm. They possess a cytoplasmic domain retrieval signal KKXX or KXKXX (where X can apparently correspond to any amino acid residue.

General

signal recognition sequence (SRS) cytoplasmic motif

References

- Luzio JP, Banting G. Eukaryotic membrane traffic: retrieval and retention mechanisms to achieve organelle residence. Trends Biochem Sci. 1993 Oct;18(10):395-8. Review. PMID: 8256290