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KiSS-1 receptor (KiSS-1R, kisspeptins receptor, metastin receptor, G-protein coupled receptor 54, hypogonadotropin-1, hOT7T175, KISS1R, AXOR12, GPR54, OT7T175)
Function:
1) receptor for metastin
2) inhibits cell proliferation & cell migration
3) cell cycle arrest & induction of apoptosis in malignant cells
4) role in normal gonadotropin-releasing hormone physiology & in puberty
5) regulation of gonadotropic axis at puberty & in adulthood
6) regulation & fine-tuning of trophoblast invasion generated by the trophoblast
7) coupling to phospholipase C & intracellular Ca+2 release via pertussis toxin-insensitive Gq proteins
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane
Expression:
- expressed in the pancreas, placenta, spinal cord > peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands, lymph nodes
- in adult brain, expressed in superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons, amygdala, hypothalamus, pituitary
Pathology:
- defects in KISS1R are a cause of
a) hypogonadotropic hypogonadism
b) central precocious puberty
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 43 kD
entity length = 398 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-46}
MOTIF: N-glycosylation site {N10}
N-glycosylation site {N18}
N-glycosylation site {N28}
transmembrane domain {47-67}
cytoplasmic loop {68-78}
transmembrane domain {79-101}
exoplasmic loop {102-120}
MOTIF: cysteine residue {C115}
MODIFICATION: cysteine residue {C191}
transmembrane domain {121-138}
cytoplasmic loop {139-157}
transmembrane domain {158-178}
exoplasmic loop {179-202}
MOTIF: cysteine residue {C191}
MODIFICATION: cysteine residue {C115}
transmembrane domain {203-223}
cytoplasmic loop {224-263}
transmembrane domain {264-284}
exoplasmic loop {285-305}
transmembrane domain {306-328}
cytoplasmic domain {329-398}
Database Correlations
OMIM correlations
MORBIDMAP 604161
UniProt Q969F8
Pfam PF00001
References
- UniProt :accession Q969F8
- protein Spotlight; Tintin's blight - Issue 58 of may 2005
http://www.expasy.org/spotlight/back_issues/sptlt058.shtml
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KISS1R