Search
metastasis-suppressor KiSS-1; Kisspeptin-1; contains: metastin, Kisspeptin-54, Kisspeptin-14, Kisspeptin-13, Kisspeptin-10 (KISS1)
Function:
1) metastasis suppressor protein in malignant melanomas & some breast cancers
2) regulation of events downstream of cell-matrix adhesion (putative)
3) cytoskeletal reorganization (putative)
4) diminishes MMP9 expression by effecting diminished NF-kappaB binding to the promoter
5) generates C-terminally amidated peptide, metastin, endogenous ligand of Kiss1R
6) Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself
7) the receptor is also essential for normal gonadotropin-releasing hormone physiology & for puberty
8) the hypothalamic KiSS1/Kiss1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty & in adulthood
9) processed by MMP2 & MMP9
Structure:
- belongs to the KISS1 family
Compartment:
- secreted
Expression:
- expressed in placenta > testis > pancreas, liver, small intestine, brain
- expression levels increased in both early placentas & molar pregnancies & are reduced in choriocarcinoma cells
- expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast
Pathology:
- down-regulated during the progression of melanoma in vivo
Related
KiSS-1 receptor (KiSS-1R, kisspeptins receptor, metastin receptor, G-protein coupled receptor 54, hypogonadotropin-1, hOT7T175, KISS1R, AXOR12, GPR54, OT7T175)
metatsin (kisspeptin-54, kp-54)
General
anti-oncoprotein (tumor suppressor protein)
phosphoprotein
protein precursor
secreted protein
Properties
SIZE: entity length = 138 aa
MW = 15 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
Essential for receptor binding and receptor activation {112-121}
MOTIF: Tyr phosphorylation site {Y112}
proteolytic site {118-119}
Database Correlations
OMIM 603286
UniProt Q15726
Entrez Gene 3814
Kegg hsa:3814
References
- UniProt :accession Q15726
- Protein Spotlight; Note: Tintin's blight, Issue 58 of May 2005
http://www.expasy.org/spotlight/back_issues/sptlt058.shtml