Search
kin of IRRE-like protein 2; kin of irregular chiasm-like protein 2; nephrin-like protein 3 (KIRREL2, NEPH3, UNQ5827/PRO19646)
Function:
- interacts with C-terminus of NPHS2/podocin
- interacts with NPHS1 via Ig domains (putative)
Structure:
- belongs to the immunoglobulin superfamily
- contains 5 Ig-like C2-type domains
Compartment:
- membrane: single-pass type 1 membrane protein
Alternative splicing: named isoforms=4
Expression:
- expressed in beta-cells of pancreatic islets
Related
nephrin; renal glomerulus-specific cell adhesion receptor (NPHS1 NPHN)
General
glycoprotein
membrane protein
Properties
SIZE: MW = 75 kD
entity length = 708 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {24-118}
MOTIF: cysteine residue {C45}
MODIFICATION: cysteine residue {C103}
cysteine residue {C103}
MODIFICATION: cysteine residue {C45}
immunoglobulin superfamily domain {123-222}
MOTIF: N-glycosylation site {N143}
cysteine residue {C146}
MODIFICATION: cysteine residue {C204}
Cell attachment {149-151}
cysteine residue {C204}
MODIFICATION: cysteine residue {C146}
immunoglobulin superfamily domain {227-307}
MOTIF: cysteine residue {C248}
MODIFICATION: cysteine residue {C291}
cysteine residue {C291}
MODIFICATION: cysteine residue {C248}
N-glycosylation site {N301}
immunoglobulin superfamily domain {312-394}
MOTIF: cysteine residue {C333}
MODIFICATION: cysteine residue {C375}
cysteine residue {C375}
MODIFICATION: cysteine residue {C333}
immunoglobulin superfamily domain {398-501}
MOTIF: cysteine residue {C419}
MODIFICATION: cysteine residue {C485}
N-glycosylation site {N484}
cysteine residue {C485}
MODIFICATION: cysteine residue {C419}
transmembrane domain {511-531}
glutamate-rich region {565-568}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 626-702
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 607762
UniProt Q6UWL6
PFAM correlations
Entrez Gene 84063
Kegg hsa:84063
References
UniProt :accession Q6UWL6