Kinetochore protein Nuf2 (hNuf2, hNuf2R, hsNuf2, cell division cycle-associated protein 1, NUF2, CDCA1, NUF2R)

Function: - component of kinetochore-associated NDC80 complex - may interact with AURKB/Aurora-B - can be phosphorylated by AURKA & AURKB Structure: belongs to the NUF2 family Compartment: - nucleus, kinetochore - localizes to kinetochores from late prophase to anaphase - localizes specifically to the outer plate of the kinetochore

General

cell division cycle-associated protein 4 (CDCA) kinetochore protein phosphoprotein

Properties

SIZE: MW = 54 kD entity length = 464 aa COMPARTMENT: cell nucleus MOTIF: KNTC2 interaction {1-385} MOTIF: coiled coil {147-345} Ser phosphorylation site {S247} KNTC2 & SPBC24-SPBC25 interaction {386-464} MOTIF: coiled coil {389-459}

Database Correlations

UniProt Q9BZD4 Pfam PF03800

References

UniProt :accession Q9BZD4