kinetochore-associated protein 1 (rough deal homolog, hRod, HsROD, Rod, KNTC1, KIAA0166)

Function: 1) component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis 2) assembly of the dynein-dynactin complex onto kinetochores 3) interacts with ZW10, required for stable association with kinetochore Compartment: - cytoplasm, nucleus, kinetochore, spindle - dynamic pattern of localization during the cell cycle - at interphase, uniformly distributed throughout the cytoplasm & nucleus - by prophase & until late stages of prometaphase, some is concentrated at kinetochores - by metaphase, at kinetochores, along spindle fibers & most prominent at the poles - by late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at spindle poles Expression: high expression in testis

Properties

SIZE: MW = 251 kD entity length = 2209 aa COMPARTMENT: cytoplasm cell nucleus

Database Correlations

OMIM 607363 UniProt P50748

References

UniProt :accession P50748