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kinesin-like 4 protein; kinesin-like DNA-binding protein; origin of plasmid DNA replication-binding protein; kinesin-like protein KIF22 (KNSL4, KIF22, KID, OBP)

Function: - involved in spindle formation & movements of chromosomes during mitosis & meiosis - binds to microtubules & to DNA - ubiquitinated, mediated by SIAH1 & leading to its subsequent proteasomal degradation (probable) - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the kinesin-like protein family - contains 1 kinesin-motor domain Compartment: - nucleus - KNSL4 colocalizes with mitotic chromosomes - enriched in the kinetochore at anaphase

General

DNA-binding protein kinesin family protein phosphoprotein

Properties

SIZE: entity length = 665 aa MW = 73 kD COMPARTMENT: cell nucleus MOTIF: kinesin motor domain SITE: 40-299 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 127-134 binding site FOR-BINDING-OF: microtubule Ser phosphorylation site {S452} coiled coil {465-508} Ser phosphorylation site {S543} Ser phosphorylation site {S562} Ser phosphorylation site {S581}

Database Correlations

OMIM 603213 UniProt Q14807 Pfam PF00225 Kegg hsa:3835

References

  1. OMIM :accession 603213
  2. UniProt :accession Q14807