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kinesin family member C1 (Kifc1, kinesin-like protein 2, kinesin-related protein HSET, KIFC1, HSET, KNSL2)
Function:
- minus end-directed microtubule-dependent motor required for bipolar spindle formation
- may contribute to movement of early endocytic vesicles
- binds NUBP1 & NUBP2 (putative)
Structure:
- belongs to the kinesin-like protein family, NCD subfamily
- contains 1 kinesin-motor domain
Compartment:
- nucleus (putative)
- centrosome, spindle
- early endosome
- associated with nucleus during interphase, centrosomes in early & spindle in later mitosis (putative)
Pathology:
- HeLa cells lacking KIFC1 show multipolar mitotic spindles & a defect in chromosome congression & chromosome alignment during mitosis
General
kinesin family protein
nuclear protein
phosphoprotein
Properties
SIZE: MW = 74 kD
entity length = 673 aa
COMPARTMENT: cytoplasm
MOTIF: coiled coil {142-306}
kinesin motor domain
SITE: 307-594
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 410-417
binding site
FOR-BINDING-OF: microtubule
Database Correlations
OMIM 603763
UniProt Q9BW19
Pfam PF00225
Entrez Gene 3833
Kegg hsa:3833
References
UniProt :accession Q9BW19