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kinectin; kinesin receptor; CG-1 antigen (KTN1, CG1, KIAA0004)
Function:
1) receptor for kinesin
2) kinesin-driven vesicle motility
2) accumulates in integrin-based adhesion complexes upon integrin aggregation by fibronectin
3) parallel homodimers formed between the membrane-bound & cytosolic form, & also between 2 cytosolic forms
Compartment:
- endoplasmic reticulum
- vesicle membrane protein anchored to endoplasmic reticulum
Alternative splicing: named isoforms=2
Expression:
- expressed in peripheral blood lympocytes, testis, ovary > spleen, thymus, prostate, small intestine, colon
Pathology: defects in KTN1 may be a cause of breast cancer
General
glycoprotein
membrane protein
phosphoprotein
receptor
Properties
SIZE: entity length = 1357 aa
MW = 156 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {7-29}
Ser phosphorylation site {S75}
Ser phosphorylation site {S77}
Thr phosphorylation site {T153}
Ser phosphorylation site {S156}
N-glycosylation site {N172}
coiled coil {330-1356}
MOTIF: N-glycosylation site {N435}
N-glycosylation site {N772}
N-glycosylation site {N904}
N-glycosylation site {N1055}
N-glycosylation site {N1088}
N-glycosylation site {N1263}
N-glycosylation site {N1329}
Database Correlations
OMIM 600381
UniProt Q86UP2
Entrez Gene 3895
Kegg hsa:3895
References
- Kumar J, Yu H, Sheetz MP.
Kinectin, an essential anchor for kinesin-driven vesicle motility.
Science. 1995 Mar 24;267(5205):1834-7.
PMID: 7892610
- UniProt :accession Q86UP2