fermitin family homolog 3; kindlin-3; MIG2-like protein; Unc-112-related protein 2 (FERMT3, KIND3, MIG2B, URP2)

Function: - plays a central role in cell adhesion in hematopoietic cells - acts by activating integrin beta-1-3 (ITGB1, ITGB2 & ITGB3) - required for integrin-mediated platelet adhesion & leukocyte adhesion to endothelial cells - required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (putative) - isoform 2 may act as a repressor of NF-kappa-B & apoptosis - interacts with ITGB1, ITGB2 & ITGB3 (via cytoplasmic tails) (putative) Structure: - the FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain - belongs to the kindlin family - contains 1 FERM domain - contains 1 PH domain Compartment: - cell projection, podosome (putative) - present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells (putative) Alternative splicing: named isoforms=2 Expression: - highly expressed in lymph node - expressed in thymus, spleen & leukocytes - weakly expressed in placenta, small intestine, stomach, testis & lung Pathology: - defects in FERMT3 are the cause of leukocyte adhesion deficiency-3 - overexpressed in B-cell malignancies

Properties

SIZE: entity length = 667 aa MW = 76 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S8} Tyr phosphorylation site {Y11} lysine-rich region {147-155} MOTIF: lysine residue (SEVERAL) FERM domain NAME: FERM domain SITE: 229-558 MOTIF: PH domain {354-457} Tyr phosphorylation site {Y504}

Database Correlations

OMIM correlations MORBIDMAP 607901 UniProt Q86UX7 PFAM correlations Entrez Gene 83706 Kegg hsa:83706

References

UniProt :accession Q86UX7