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fermitin family homolog 2; kindlin-2; mitogen-inducible gene 2 protein; MIG-2; pleckstrin homology domain-containing family C member 1; PH domain-containing family C member 1 (FERMT2, KIND2, MIG2, PLEKHC1)
Function:
- role in the connection between ECM adhesion sites & the actin cytoskeleton & also in the orchestration of actin assembly & cell shape modulation
- recruits migfilin (FBLP1) protein to cell-extracellular matrix focal adhesion sites
- interacts with FBLP1
Structure:
- the FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain
- belongs to the kindlin family
- contains 1 FERM domain
- contains 1 PH domain
Compartment:
- cytoplasm, cell cortex, cytoskeleton
- cell junction, focal adhesion
- within actin stress fibers at cell-ECM focal adhesion sites
Alternative splicing: named isoforms=2
Note: may be due to an exon inclusion & an intron retention
Expression:
- ubiquitous
- found in numerous tumor tissues
- induced by serum in lung fetal fibroblast cultured cells
General
kindlin
pleckstrin homology domain containing family
Properties
SIZE: entity length = 680 aa
MW = 78 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S159}
Ser phosphorylation site {S181}
FERM domain
NAME: FERM domain
SITE: 189-661
MOTIF: PH domain {380-476}
Ser phosphorylation site {S666}
Database Correlations
OMIM 607746
UniProt Q96AC1
PFAM correlations
Entrez Gene 10979
Kegg hsa:10979
References
- UniProt :accession Q96AC1
- Wikipedia; Note: FERMT2 entry
http://en.wikipedia.org/wiki/FERMT2