Search
Killer cell lectin-like receptor subfamily G member 1 (mast cell function-associated antigen, MAFA-like receptor, ITIM-containing receptor MAFA-L, C-type lectin domain family 15 member A) (KLRG1 CLEC15A MAFA MAFAL)
Function:
- plays an inhibitory role on natural killer (NK) cells & T-cell functions upon binding to their ligands
- binds E-cadherin/CDH1, N-cadherin/CDH2 & R-cadherin/CDH4
- forms monomer & homodimer; disulfide-linked
- interacts (via phosphorylated ITIM motif) with PTPN11 & INPP5D
Structure:
- contains 1 copy of ITIM motif
- contains 1 C-type lectin domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed specifically on natural killer cells (NK cells) & T-cells, mainly CD8 T-cells
Pathology: induced by pathogens & viruses infections
General
glycoprotein
killer cell lectin like receptor
Properties
SIZE: entity length = 195 aa
MW = 22 kD
COMPARTMENT: cellular membrane
MOTIF: immunoreceptor tyrosine-based inhibitory motif (ITIM) {5-10}
serine-rich region {28-31}
MOTIF: serine residue (SEVERAL)
transmembrane domain {39-59}
N-glycosylation site {N65}
C-type lectin {82-185}
MOTIF: N-glycosylation site {N97}
cysteine residue {C103}
MODIFICATION: cysteine residue {C184}
N-glycosylation site {N137}
N-glycosylation site {N150}
cysteine residue {C163}
MODIFICATION: cysteine residue {C176}
cysteine residue {C176}
MODIFICATION: cysteine residue {C163}
cysteine residue {C184}
MODIFICATION: cysteine residue {C103}
Database Correlations
OMIM 604874
UniProt Q96E93
Pfam PF00059
Entrez Gene 10219
Kegg hsa:1021
References
UniProt :accession Q96E93