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killer cell lectin-like receptor subfamily F member 2; lectin-like receptor F2; activating coreceptor NKp65 (KLRF2)
Function:
- C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity & cytokine secretion in keratinocytes via its interaction with CLEC2A
- interacts with CLEC2A
Structure:
- N-glycosylated
- homodimer; non disulfide-linked
- contains 1 C-type lectin domain
Compartment:
- cell membrane; single-pass type 2 membrane protein
General
glycoprotein
membrane protein
receptor
Properties
SIZE: entity length = 207 aa
MW = 24 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {31-51}
N-glycosylation site {N67}
C-type lectin {85-194}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C193}
cysteine residue {C172}
MODIFICATION: cysteine residue {C185}
cysteine residue {C185}
MODIFICATION: cysteine residue {C172}
cysteine residue {C193}
MODIFICATION: cysteine residue {C106}
N-glycosylation site {N202}
Database Correlations
UniProt D3W0D1
Pfam PF00059
Entrez Gene 100431
Kegg hsa:100431
References
UniProt :accession D3W0D1