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killer cell lectin-like receptor subfamily F member 1; lectin-like receptor F1; activating coreceptor NKp80; C-type lectin domain family 5 member C (KLRF1, CLEC5C, ML)
Function:
- role in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts
Structure:
- homodimer
- contains 1 C-type lectin domain
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- strongly expressed in peripheral blood leukocytes & spleen,
- weaker expression in lymph node & adult liver
- no expression in bone marrow, thymus, & fetal liver
- not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, & pancreas
- within peripheral blood leukocyte & immunocyte cell lines, expression is predominant in NK cells but also expressed in monocytes
General
glycoprotein
human longevity protein
killer cell lectin like receptor
Properties
SIZE: entity length = 232 aa
MW = 27 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {39-59}
N-glycosylation site {N77}
N-glycosylation site {N91}
N-glycosylation site {N96}
C-type lectin {121-231}
MOTIF: cysteine residue {C143}
MODIFICATION: cysteine residue {C230}
N-glycosylation site {N177}
cysteine residue {C209}
MODIFICATION: cysteine residue {C222}
cysteine residue {C222}
MODIFICATION: cysteine residue {C209}
cysteine residue {C230}
MODIFICATION: cysteine residue {C143}
Database Correlations
OMIM 605029
UniProt Q9NZS2
Pfam PF00059
Entrez Gene 51348
Kegg hsa:5134
References
- UniProt :accession Q9NZS2
- Functional Glycomics gateway - Glycan binding; Note: KLRF1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_241