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CD158c; killer cell immunoglobulin-like receptor like protein KIR3DP1 (KIR3DP1, CD158C, KIR2DS6, KIR48, KIRX)

Structure: - contains 3 Ig-like C2-type domains (immunoglobulin-like) Compartment: secreted (putative) Expression: - expressed in peripheral blood cells Genetics: - chromosomal rearrangement producing a recombinant gene composed of the promoter & first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene; this leads to the expression in 4.5% of a Spanish Caucasoid population of an mRNA which may encode a chimeric protein KIR2DL5A/KIR3DP1 [2] Notes: - UniProt entry deleted

Related

killer cell inhibitory receptor; killer cell immunoglobulin like receptor (KIR)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein secreted protein

Properties

SIZE: entity length = 328 aa MW = 36 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-21} immunoglobulin superfamily domain {42-97} MOTIF: cysteine residue {C49} MODIFICATION: cysteine residue {C95} cysteine residue {C95} MODIFICATION: cysteine residue {C49} immunoglobulin superfamily domain {137-197} MOTIF: cysteine residue {C144} MODIFICATION: cysteine residue {C195} N-glycosylation site {N162} cysteine residue {C195} MODIFICATION: cysteine residue {C144} immunoglobulin superfamily domain {237-295} MOTIF: cysteine residue {C244} MODIFICATION: cysteine residue {C293} cysteine residue {C293} MODIFICATION: cysteine residue {C244}

Database Correlations

OMIM 610604 Pfam PF00047

References

  1. UniProt :accession A8MWS1
  2. Gomez-Lozano N, Estefania E, Williams F, Halfpenny I et al The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. Eur J Immunol. 2005 Jan;35(1):16-24. PMID: 1558065