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killer cell immunoglobulin-like receptor 3DS1; MHC class I NK cell receptor; natural killer-associated transcript 10; NKAT-10 (KIR3DS1, NKAT10)
Function:
- receptor on natural killer (NK) cells for HLA-C alleles
- does not inhibit the activity of NK cells
Structure:
- belongs to the immunoglobulin superfamily
- contains 3 Ig-like C2-type domain (immunoglobulin-like)
Compartment: cell membrane
Expression:
- expressed in NK cells & T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line
Polymorphism:
- the KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that has undergone expansion & contraction over time, probably through unequal crossing-over; thus, KIR haplotypes vary in the number & types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearly all haplotypes.
- KIR3DL1 & KIR3DS1 segregate as alleles of the locus KIR3DL1/3DS1
General
glycoprotein
killer cell immunoglobulin like receptor 3DS (KIR3DS)
Properties
SIZE: entity length = 387 aa
MW = 43 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {42-102}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C95}
N-glycosylation site {N92}
cysteine residue {C95}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {137-202}
MOTIF: cysteine residue {C144}
MODIFICATION: cysteine residue {C195}
N-glycosylation site {N179}
cysteine residue {C195}
MODIFICATION: cysteine residue {C144}
immunoglobulin superfamily domain {237-300}
MOTIF: cysteine residue {C244}
MODIFICATION: cysteine residue {C293}
N-glycosylation site {N273}
cysteine residue {C293}
MODIFICATION: cysteine residue {C244}
transmembrane domain {341-360}
Database Correlations
OMIM 604946
UniProt Q14943
Pfam PF00047
Entrez Gene 3813
References
- UniProt :accession Q14943
- http://mpr.nci.nih.gov/prow/guide/1741688733_g.htm
- Entrez Gene :accession 3813