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killer cell immunoglobulin-like receptor 2DS3; MHC class I NK cell receptor; natural killer-associated transcript 7; NKAT-7 (KIR2DS3, NKAT7)
Function:
- receptor on natural killer (NK) cells for HLA-C alleles
- does not inhibit the activity of NK cells
Structure:
- belongs to the immunoglobulin superfamily
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment: cell membrane
General
glycoprotein
killer cell immunoglobulin like receptor 2DS (KIR2DS)
Properties
SIZE: entity length = 304 aa
MW = 34 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {42-107}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C100}
N-glycosylation site {N67}
N-glycosylation site {N84}
cysteine residue {C100}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {142-205}
MOTIF: cysteine residue {C149}
MODIFICATION: cysteine residue {C198}
N-glycosylation site {N178}
cysteine residue {C198}
MODIFICATION: cysteine residue {C149}
transmembrane domain {246-264}
Database Correlations
OMIM 604954
UniProt Q14952
Pfam PF00047
Entrez Gene 3808
Kegg hsa:3808
References
- UniProt :accession Q14952
- http://mpr.nci.nih.gov/prow/guide/397488963_g.htm
- Entrez Gene :accession 3808