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killer cell immunoglobulin-like receptor 2DL5B (killer cell immunoglobulin-like receptor 2DLX, CD158f2 antigen, KIR2DL5B, CD158F, CD158F2, KIR2DL5, KIR2DLX)
Function:
- receptor on natural killer (NK) cells for HLA-C alleles
- inhibits the activity of NK cells thus preventing cell lysis
Structure:
- belongs to the immunoglobulin superfamily
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment: membrane
General
glycoprotein
killer cell immunoglobulin-like receptor 2DL5 (KIR2DL5)
Properties
SIZE: entity length = 375 aa
MW = 41 kD
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {42-102}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C95}
cysteine residue {C95}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {137-200}
MOTIF: cysteine residue {C144}
MODIFICATION: cysteine residue {C193}
cysteine residue {C193}
MODIFICATION: cysteine residue {C144}
N-glycosylation site {N218}
serine-rich region {219-225}
MOTIF: serine residue (SEVERAL)
transmembrane domain {239-259}
Database Correlations
OMIM 605305
UniProt Q8NHK3
Pfam PF00047
Entrez Gene 553128
References
UniProt :accession Q8NHK3