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killer cell immunoglobulin-like receptor 2DL4; MHC class I NK cell receptor KIR103AS; killer cell inhibitory receptor 103AS; KIR-103AS; G9P; CD158 antigen-like family member D; CD158d (KIR2DL4, CD158D, KIR103AS)
Function:
- receptor on natural killer (NK) cells for HLA-C alleles
- inhibits the activity of NK cells thus preventing cell lysis
Structure:
- belongs to the immunoglobulin superfamily
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment: cell membrane
Alternative splicing: named isoforms=6
General
CD158
glycoprotein
killer cell immunoglobulin like receptor 2DL (KIR2DL)
Properties
SIZE: entity length = 377 aa
MW = 42 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {44-104}
MOTIF: cysteine residue {C51}
MODIFICATION: cysteine residue {C97}
cysteine residue {C97}
MODIFICATION: cysteine residue {C51}
immunoglobulin superfamily domain {139-202}
MOTIF: N-glycosylation site {N141}
cysteine residue {C146}
MODIFICATION: cysteine residue {C195}
N-glycosylation site {N175}
cysteine residue {C195}
MODIFICATION: cysteine residue {C146}
transmembrane domain {243-263}
Database Correlations
OMIM 604945
UniProt Q99706
Pfam PF00047
Entrez Gene 3805
References
- UniProt :accession Q99706
- http://mpr.nci.nih.gov/prow/guide/1380098759_g.htm
- Entrez Gene :accession 3805