KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1, SLM-1, hSLM-1, KHDRBS2, SLM1)

Function: - RNA-binding protein - role in the regulation of alternative splicing & influences mRNA splice site selection & exon inclusion - phosphorylation by FYN inhibits its ability to regulate splice site selection - induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer - may function as an adapter protein for Src kinases during mitosis. - binds both poly(A) & poly(U) homopolymers - phosphorylation by PTK6 inhibits its RNA-binding ability (putative) - self-associates to form homo-oligomers - interacts with RBMX, SAFB, SFRS9 & YTHDC1 - found in a complex with KHDRBS1, KHDRBS2 & KHDRBS3 - interacts with SH3 domains of FYN & PLCG1 - interacts with SH2 domains of FYN, GRAP2, PLCG1 & RASA1 (putative) - methylated - tyrosine phosphorylated by FYN, PTK6 & SRC - tyrosine phosphorylated by SRC during mitosis (putative) Structure: - belongs to the KHDRBS family - contains 1 KH domain Compartment: nucleus (putative) Expression: - expressed in brain, lung, kidney & small intestine > placenta, liver, spleen, thymus, ovary & colon

General

nuclear protein RNA-binding protein

Properties

SIZE: entity length = 349 aa MW = 39 kD COMPARTMENT: cell nucleus MOTIF: KH domain SITE: 65-135 FOR-BINDING-OF: ribonucleic acid proline-rich region SITE: 211-262 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q5VWX1 Pfam PF00013

References

UniProt :accession Q5VWX1