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CDw131; cytokine receptor common subunit beta; KH97; GM-CSF/IL-3/IL-5 receptor common beta-chain; CDw131; CD131 (CSF2RB, IL3RB, IL5RB)
Function:
1) beta subunit is common to
a) IL3 receptor
b) IL5 receptor
c) GM-CSF receptors (IL3R, IL5R &
2) associates with:
a) IL-3 receptor alpha
b) IL-5 receptor alpha
c) GM-CSF receptor alpha
Structure:
- the WSXWS motif appears to be necessary for proper protein folding & thereby efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type 1 cytokine receptor family, type 4 subfamily
- contains 2 fibronectin F3 modules
Compartment: membrane
Alternative splicing: named isoforms=2
Pathology:
- defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
cytokine receptor
glycoprotein
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 897 aa
MW = 97 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-16}
cysteine residue {C35}
MODIFICATION: cysteine residue {C45}
cysteine residue {C45}
MODIFICATION: cysteine residue {C35}
N-glycosylation site {N58}
cysteine residue {C75}
MODIFICATION: cysteine residue {C96}
cysteine residue {C86}
MODIFICATION: cysteine residue {C91}
cysteine residue {C91}
MODIFICATION: cysteine residue {C86}
cysteine residue {C96}
MODIFICATION: cysteine residue {C75}
fibronectin type III domain or F3 module {133-233}
MOTIF: N-glycosylation site {N191}
cysteine residue {C250}
MODIFICATION: cysteine residue {C260}
cysteine residue {C260}
MODIFICATION: cysteine residue {C250}
cysteine residue {C289}
MODIFICATION: cysteine residue {C306}
cysteine residue {C306}
MODIFICATION: cysteine residue {C289}
fibronectin type III domain or F3 module {338-432}
MOTIF: N-glycosylation site {N346}
WSXWS motif {425-429}
transmembrane domain {444-460}
box1 motif
SITE: 474-482
FOR-BINDING-OF: Janus Kinase 2 (JAK2)
Tyr phosphorylation site {Y766}
Database Correlations
OMIM correlations
UniProt P32927
Pfam PF00041
Entrez Gene 1439
Kegg hsa:1439
References
- UniProt :accession P32927
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CSF2RB
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- Ihle JN et al
Signaling by the cytokine receptor superfamily: JAKs and STATs
TIBS 19:222 1994
PMID: 8048164
Component-of
granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor or colony stimulating factor receptor 2