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ketotifen (Zaditor, Zaditen, Alaway, Claritin Eye, Zyrtec Itchy Eye Drops)

Tradenames: Zaditor, Zaditen, Alaway, Claritin Eye, Zyrtec Itchy Eye Drops Indications: -> allergic conjunctivitis Dosage: 1 drop in affected eye(s) BID Ophthalmic solution: 0.025%, 1 mL, 5 mL 0.345 mg ketotifen fumarate (0.25 mg ketotifen)/mL Contains: glycerol, benzalkonium chloride 0.01% pH: 4.4-5.8, osmolality 210-300 mOsm/kg Storage: 4-25 C Pharmacokinetics: -> systemic concentrations below detection (20 pg/mL) after topical administration Adverse effects: 1) ocular: -> allergic reactions, conjunctivitis, eye pain, keratitis, mydriasis, photophobia, rash 2) non-ocular -> flu-like syndrome, pharyngitis Toxicity: -> no serious toxicity after ingestion of 20 mg of ketotifen fumarate (1.725 mg/5 mL bottle) Mechanism of action: 1) non-competitive histamine H1 receptor antagonist 2) mast cell stabilizer 3) decreased chemotaxis & activation of eosinophils

Interactions

drug adverse effects of H1 receptor antagonists

General

H1 receptor antagonist (antihistamine) mast cell stabilizer

Properties

SIZE: MW = 425.5 G/MOLE MISC-INFO: pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. Novartis
  2. Prescriber's Letter 14(1): 2007 Ophthalmic Medications for Allergic Conjunctivitis Detail-Document#: 230106 (subscription needed) http://www.prescribersletter.com
  3. Prescriber's Letter 16(10): 2009 CHART: OTC Brand Name Extensions COMMENTARY: Brand Name Extensions, Reformulations, and Labeling Revisions of OTC Products Detail-Document#: 251012 (subscription needed) http://www.prescribersletter.com