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ketosis prone diabetes; flatbush diabetes, type 1B diabetes, atypical diabetes

pathology: - episodic diabetic ketoacidosis resulting from insulin deficiency - variable periods of insulin dependence & independence - islet beta-cells impaired by glucose toxicity Laboratory: - C-peptide in serum weeks to months after episode of iabetic ketoacidosis - islet beta-cell function confirmed by C-peptide in serum > 1 ng/mL - glutamic acid decarboxylase Ab in serum to evaluate for type 1 diabetes Management: - treatment of diabetic ketoacidosis (DKA) - if islet beta-cell function confirmed & type 1 diabetes unlikely, insulin may be discontinued & metformin started

General

diabetes mellitus

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022