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keratan sulfate proteoglycan keratocan
Function:
- developing & maintaining corneal transparency & for the structure of the stromal matrix
- binds keratan sulfate chains
Structure:
- belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
- contains 10 LRR repeats (leucine-rich repeats)
- contains 1 LRRNT domain
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- cornea
- trachea
- low levels in intestine, skeletal muscle, ovary, lung & putamen
Pathology:
- mutations associated with autosomal recessive cornea plana 2
- increased expression in keratoconus
Specific
Keratocan Topical
General
keratan sulfate proteoglycan
secreted protein
Properties
SIZE: MW = 41 kD
entity length = 352 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine-rich region {42-58}
LRR-S {64-83}
LRR-T {84-107}
MOTIF: N-glycosylation site {N93}
LRR-T {108-133}
LRR-S {134-154}
LRR-T {155-178}
MOTIF: N-glycosylation site {N167}
LRR-T {179-204}
LRR-S {205-225}
MOTIF: N-glycosylation site {N222}
LRR-T {226-249}
LRR-T {250-274}
LRR-S {275-294}
N-glycosylation site {N298}
cysteine residue {C303}
MODIFICATION: cysteine residue {C343}
LRR-T {309-332}
LRR-T {333-352}
MOTIF: cysteine residue {C343}
MODIFICATION: cysteine residue {C303}
Database Correlations
OMIM correlations
UniProt O60938
Pfam PF01462
Entrez Gene 11081
Kegg hsa:11081
References
UniProt O60938
Components
hyaluronate; hyaluronic acid; hyaluronan
proteoglycan core protein
proteoglycan link protein; cartilage link protein