kelch-like protein 20; kelch-like ECT2-interacting protein; kelch-like protein X (KLHL20, KLEIP)

Function: - substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response - also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases - protein modification; protein ubiquitination - interacts with DAPK1 - interacts with F-actin - interacts with IFN-gamma (IFNG) Structure: - contains 1 BACK (BTB/kelch associated) domain - contains 1 BTB/POZ domain - contains 6 kelch repeats Compartment: - cytoplasm, perinuclear region, nucleus - localizes in the perinuclear region in normal conditions - following IFN-alpha or IFN-gamma treatment, it is relocalized & sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination

Properties

SIZE: entity length = 609 aa MW = 68 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: BTB domain {68-135} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 BACK {170-272} kelch repeat {319-365} kelch repeat {367-413} kelch repeat {414-460} kelch repeat {462-507} kelch repeat {509-554} kelch repeat {556-601}

Database Correlations

UniProt Q9Y2M5 PFAM correlations Entrez Gene 27252 Kegg hsa:27252

References

UniProt :accession Q9Y2M5