kelch-like protein 41; kel-like protein 23; kelch repeat & BTB domain-containing protein 10; kelch-related protein 1; sarcosin (KLHL41, KBTBD10, KRP1)

Function: - role in skeletal muscle development & differentiation - regulates proliferation & differentiation of myoblasts - role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils - required for pseudopod elongation in transformed cells - substrate-specific adapter of BCR E3 ubiquitin ligase complex that contains CUL3, RBX1 & KBTBD10 - protein modification; protein ubiquitination - ubiquitinated & probably targeted for proteasome- independent degradation - quinone-induced oxidative stress increases its ubiquitination - interacts with NRAP (putative) - interacts with LASP1 Structure: - contains 1 BACK (BTB/kelch associated) domain - contains 1 BTB/POZ domain - contains 5 kelch repeats Compartment: - cytoplasm. cytoplasm, cytoskeleton - cell projection, pseudopodium, ruffle - sarcomere, M line (putative) - predominantly cytoplasmic but can co-localize with F-actin at membrane ruffle-like structures at the tips of transformation-specific pseudopodia Alternative splicing: named isoforms=2; long, short Expression: sarcomeric muscle

General

cytoskeletal protein kelch-like protein Kelch repeat & BTB domain containing protein

Properties

SIZE: entity length = 606 aa MW = 68 kD COMPARTMENT: cytoplasm MOTIF: BTB domain {33-100} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 BACK {135-237} kelch repeat {346-398} kelch repeat {399-447} kelch repeat {448-495} kelch repeat {497-542} kelch repeat {544-599}

Database Correlations

OMIM 607701 UniProt O60662 PFAM correlations Entrez Gene 10324 Kegg hsa:10324

References

UniProt :accession O60662