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kelch-like protein 3 (KLHL3 KIAA1129)
Function:
- probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex that mediates ubiquitination & subsequent proteasomal degradation of target proteins
- protein modification; protein ubiquitination
- interacts with CUL3
Structure:
- contains 1 BTB/POZ domain
- contains 6 kelch repeats
Compartment:
- cytoplasm, cytoskeleton
Alternative splicing: named isoforms=3; A, B, C
Expression:
- expressed in many tissues
General
kelch-like protein
Properties
SIZE: entity length = 587 aa
MW = 65 kD
COMPARTMENT: cytoplasm
MOTIF: BTB domain {50-117}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
kelch repeat {302-347}
kelch repeat {348-394}
kelch repeat {396-441}
kelch repeat {442-490}
kelch repeat {491-537}
kelch repeat {539-585}
Database Correlations
OMIM 605775
UniProt Q9UH77
PFAM correlations
Entrez Gene 26249
Kegg hsa:26249
References
UniProt :accession Q9UH77