Kelch-like protein 12 (CUL3-interacting protein 1, KLHL12, C3IP1)

Function: 1) serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex 2) negatively regulates Wnt signaling pathway via targeted ubiquitination & subsequent proteolysis of DVL3 3) component of ubiquitin-protein E3 ligase complex which includes CUL3 & KLHL12 - complex interacts with DVL3 upon activation of Wnt signaling pathway by WNT3A Structure: - BTB domain is required for interaction with CUL3 contains 1 BTB domain (POZ domain contains 6 Kelch repeats Expression: - expressed in testis & at lower levels in submandibular salivary gland

Properties

SIZE: MW = 63 kD entity length = 568 aa COMPARTMENT: cytoplasm MOTIF: BTB domain {33-100} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 kelch repeat {282-329} kelch repeat {331-379} kelch repeat {380-426} interaction with DVL3 {405-568} MOTIF: kelch repeat {427-473} kelch repeat {475-520} kelch repeat {522-567}

Database Correlations

UniProt Q53G59 PFAM correlations

References

UniProt :accession Q53G59