kelch domain-containing protein 5; kelch-like protein 42; Cullin-3-binding protein 9; Ctb9 (KLHL42, KIAA1340, KLHDC5)

Function: - component of the BCR(KLHL42) E3 ubiquitin ligase complex - substrate-specific adapter of the complex - required for progression & cytokinesis - the BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination & subsequent degradation of KATNA1 - role in microtubule dynamics throughout mitosis - interacts (via the BTB domain) with CUL3. - interacts (via the kelch domains) with KATNA1 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - contains 1 BTB (POZ) domain - contains 6 Kelch repeats Compartment: - cytoplasm, cytoskeleton, spindle - predominantly in mitotic cells - localized diffusely in the cytoplasm during the interphase - during metaphase is localized throughout the cell & more widely dispersed than the microtubules - in anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles - during telophase is localized arround the nuclei of the two daughter cells - not detected at the midbody region during cytokinesis Expression: up-regulated during mitosis

General

kelch-like protein Kelch repeat & BTB domain containing protein phosphoprotein

Properties

SIZE: MW = 57 kD entity length = 505 aa COMPARTMENT: cytoplasm MOTIF: BTB domain {5-78} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S43} kelch repeat {176-234} kelch repeat {235-282} kelch repeat {284-325} kelch repeat {327-372} kelch repeat {374-429} MOTIF: Ser phosphorylation site {S410} kelch repeat {431-480}

Database Correlations

UniProt Q9P2K6 PFAM correlations Entrez Gene 57542 Kegg hsa:57542

References

UniProt :accession Q9P2K6