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kelch domain-containing protein 2; hepatocellular carcinoma-associated antigen 33; host cell factor homolog LCP; host cell factor-like protein 1; HCLP-1 (KLHDC2, HCA33)
Function:
- represses CREB3-mediated transcription by interfering with CREB3-DNA binding
- directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA & herpes simplex virus transactivator VP16
Structure: contains 6 kelch repeats
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- high expression in skeletal muscle, heart, pancreas & liver
- undetectable in peripheral blood leukocytes
General
kelch domain containing protein
nuclear protein
Properties
SIZE: entity length = 406 aa
MW = 46 kD
COMPARTMENT: cell nucleus
MOTIF: kelch repeat {43-89}
kelch repeat {102-155}
kelch repeat {157-202}
kelch repeat {229-278}
kelch repeat {280-329}
kelch repeat {331-377}
Database Correlations
OMIM 611280
UniProt Q9Y2U9
Pfam PF07646
Entrez Gene 23588
Kegg hsa:23588
References
UniProt :accession Q9Y2U9