KDEL receptor-2; ER lumen protein retaining receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; ERD2-like protein 1; ELP-1 (KDELR2, ERD22)

Function: - required for retention of luminal endoplasmic reticulum proteins - determines specificity of the luminal ER protein retention system - also required for normal vesicular traffic through the Golgi - receptor recognizes K-D-E-L (KDEL motif) Structure: belongs to the ERD2 family Compartment: endoplasmic reticulum membrane

Properties

SIZE: entity length = 212 aa MW = 24 kD COMPARTMENT: endoplasmic reticulum MOTIF: exoplasmic domain {1-2} transmembrane domain {3-21} cytoplasmic loop {22-35} transmembrane domain {36-53} exoplasmic loop {54-61} transmembrane domain {62-80} cytoplasmic loop {81-96} transmembrane domain {97-110} exoplasmic loop {111-117} transmembrane domain {118-137} cytoplasmic loop {138-149} transmembrane domain {150-168} exoplasmic loop {169-178} transmembrane domain {179-199} cytoplasmic domain {200-212}

Database Correlations

OMIM 609024 UniProt P33947 Pfam PF00810

References

UniProt :accession P33947