KDEL receptor 1; ER lumen protein retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; MAPK-activating protein PM23 (KDELR1, ERD21)

Function: - required for retention of luminal endoplasmic reticulum proteins - determines the specificity of the luminal ER protein retention system - also required for normal vesicular traffic through Golgi - recognizes K-D-E-L (KDEL motif) - interacts with ARFGAP1 (putative) Structure: belongs to the ERD2 family Compartment: endoplasmic reticulum membrane

Properties

SIZE: entity length = 212 aa MW = 25 kD COMPARTMENT: endoplasmic reticulum MOTIF: exoplasmic domain {1-2} transmembrane domain {3-21} cytoplasmic loop {22-35} transmembrane domain {36-53} exoplasmic loop {54-61} transmembrane domain {62-80} cytoplasmic loop {81-96} transmembrane domain {97-110} exoplasmic loop {111-117} transmembrane domain {118-137} cytoplasmic loop {138-149} transmembrane domain {150-168} exoplasmic loop {169-178} transmembrane domain {179-199} cytoplasmic domain {200-212}

Database Correlations

OMIM 131235 UniProt P24390 Pfam PF00810 Kegg hsa:1094

References

UniProt :accession P24390